Kalyazin is a town and the administrative center of Kalyazinsky District in Tver Oblast, Russia, located on the right bank of the Volga River.

Kalyazin contains sixteen cultural heritage monuments of federal significance and additionally twenty-two objects classified as cultural and historical heritage of local significance. The town landmark is the Kalyazin Bell Tower, submerged by the Uglich Reservoir and located only partially above the water level. Other federal monuments include the ensemble of administrative buildings and living houses in the center of the town, and the Ascension and the Epiphany Churches.